Knottins are made from an elementary motif


  • ‣ Comparison of knottins show that only two disulfides are structurally well conserved.
  • ‣ All knottins contain a well-conserved two-disulfide structural motif.
  • ‣ Knottins might have emerged from ancestral two-disulfide proteins.
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Cystine Stabilized Beta-sheet

Disulfide Directed beta-Hairpin


The DDH motif

A slightly different description has also been given and termed the DDH (Disulfide-Directed β-Hairpin) motif [Wang et al., 2000].
The DDH motif contains a β-hairpin instead of a triple-stranded β-sheet.